About ProVen Probiotics

About ProVen Probiotics

The group of bacteria used in the ProVen Probiotics range is backed by a unique body of research supporting the benefits of these bacteria for different lifestages and health complaints.

From pregnancy, through infancy and childhood and into adulthood, the Lab4 friendly bacteria used in the ProVen Probiotics products have been shown to be beneficial in protection against allergy, common illnesses and specific digestive complaints, including bloating, irritable bowel syndrome (IBS) and Clostridium difficile (C. difficile) diarrhoea. They have also been shown to be safe to use and to support gut balance during and after antibiotic therapy.

Over 30 years’ experience in probiotics…

ProVen Probiotics is owned and managed by Dr Nigel Plummer, a world-renowned expert in the field of probiotics. Dr Plummer produced his first human probiotic in 1994, having previously worked in the field of animal probiotics.

Working with his 20-strong team of scientists and researchers, around 15 years ago Dr Plummer developed Lab4, a trademarked group of four bacterial strains. The team has since developed Lab4b, a second group of four bacterial strains for babies and has also identified a new strain of bacteria (Lab4p) which has been shown to lower cholesterol.

The Lab4, Lab4b and Lab4p probiotics are the strains used in ProVen Probiotics.

ProVen is part of Cultech Ltd, a bioscience company based in south Wales, which produces supplements for a large number of companies worldwide. The company is internationally renowned as an expert in probiotic bacteria and is approved to make probiotics as medicines – the company is also BRC approved, has ISO9000 and MHRA accreditations and is audited to cGMP (current Good Manufacturing Processes) by the FDA in the USA.

Continuous research & development...

The Lab4 friendly bacteria in ProVen Probiotics is one of the most studied groups of friendly bacteria in the world and the most studied in the UK.

ProVen Probiotics are supported by a large body of ongoing research, with more than 40 published scientific papers, including nine major human studies, all demonstrating positive benefits in intestinal and immune heath.

Cultech Ltd (ProVen Probiotics’ parent company) is licensed by the MHRA to produce probiotics for clinical studies. Approval to give probiotics to almost 500 healthy newborn babies for the Swansea Baby Study is testament to the quality and safety of our products.

Probiotics are different from other supplements in that strain differences mean that benefits can be specific to an individual product and ongoing research and a detailed understanding of the developments in the probiotic industry are necessary to stay ahead of the game.

Research is at the heart of the Cultech & ProVen Probiotics operations and the company employs a large team of scientists and researchers. It has had studies published in more than 75 peer-reviewed publications and funded 16 PhDs, establishing an evidence base of health benefits to support its products.

Working with leading universities and hospitals, many in the UK, the research team work continuously to remain up-to-date with the latest industry research and developments.

Testament to this is the development of Lab4b for babies and the recent discovery of Lab4p, a brand new bacterial strain that helps to reduce cholesterol.

World-class manufacturing and production in the UK…

Manufactured at the Cultech GMP (Good Manufacturing Process) approved manufacturing facility in the UK, ProVen Probiotics are produced using proprietary manufacturing processes, Tri-Phase and StabilityMax.


Developed by the scientists at Cultech, Tri-Phase is a unique three-stage micro-encapsulation and conditioning technology, which increases stability of the probiotics at every stage of the process.


Phase 1

Micro-encapsulating and freeze-drying the probiotics

Phase 2

Pre-conditioning and tempering the product during manufacturing

Phase 3

Final treatment prior to packaging

Stability Max combines the TriPhase treated active ingredients with optimised ‘gas-tight’ packaging and ‘overage’ (extra) of bacteria.

The result is high potency probiotics, which are stable for up to 18 months at temperatures of 25-30°C. ProVen Probiotics guarantee that our products will always meet the label claim for the number of bacteria – the number on the label is the minimum count for each capsule, tablet or serving.


What Are Friendly Bacteria?
The friendly bacteria in our intestines have been termed ‘probiotics’ and they comprise the beneficial types of bacteria found in the normal microflora of the human gut...
Learn More
ProVen for the Whole Family
The group of bacteria used in the ProVen Probiotics range is backed by a unique body of research supporting the benefits of these bacteria for different lifestages...
View Products