The Sheffield IBS Trial
This randomised, double-blind, placebo controlled study investigated the effect of supplementation with Lab4 probiotics to significantly reduce the symptoms of IBS.
- The study was carried out at The University of Sheffield.
- 52 people diagnosed with IBS by the Rome II criteria were divided into two groups.
- The first group received 25 billion Lab4 probiotics daily for 8 weeks.
- The second group took a placebo preparation.
- The IBS symptoms were assessed every two weeks during the study period and again at 10 weeks – two weeks after stopping the probiotics.
- The IBS symptoms measured included:
- Number of days with pain
- Level of abdominal pain
- Quality of life
- Satisfaction with bowel habit
- A significant reduction in days with pain and bloating was achieved with the Lab4 probiotic group.
- Satisfaction with bowel habit and quality of life were significantly improved in the Lab4 probiotic group (reduction in the symptom severity scores).
The Lab4 probiotics significantly reduced total symptoms and improved quality of life in diagnosed IBS sufferers.
Continued supplementation was considered necessary to sustain this improvement.
Williams EA et al 2008.
Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study.
Alimentary Pharmacology & Therapeutics, 29: 97-103