ProVen Professional – Study – The KEELE Study

The KEELE Study

A double blind, placebo controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function

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Aim

This randomised, double blind, placebo controlled study examined the effects of Lab4 probiotics on general feelings of anxiety, mood and cognitive function in healthy individuals.

Method

  • 50 healthy volunteers (19-38 years old, BMI<30) were divided into two groups
  • One group was supplemented with 50 billion Lab4 probiotics whilst the second group took a placebo daily for 6 weeks
  • Volunteers completed mood and anxiety questionnaires (Bond Lader Mood Scales, Stait Trait Anxiety Inventory)
  • Participants also completed comprehensive computerised cognitive battery of tests (COMPASS)

The results

‘Trait’ Anxiety
(individual’s tendency to experience anxiety in response to the anticipation of a future threat, how individuals felt over the previous 6 weeks)

  • Lab4 probiotics significantly decreased ‘trait’ anxiety levels compared to placebo group, where the ‘trait’ anxiety levels increased over the course of 6 weeks supplementation (p=0.042)

‘Continuity of attention’
(ability to focus and avoid distraction)

  • Significantly increased in response to the Lab4 supplementation and decreased in the placebo group (p=0.035)

Trait Anxiety

  • Lab 4 Group
  • Placebo Group

Conclusion

The study showed the benefit of Lab4 probiotics on cognitive function in healthy individuals.

Reference

Owen L, Reinders M, Narramore R, Marsh AMR, Gar Lui F, Baron R, Plummer S, Corfe BM.
A double blind, placebo controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function.
Proceedings of the Nutrition Society 2014, 73 (OCE1): E29

Research Partners:
School of Psychology, Keele University
Department of Oncology, University of Sheffield

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