ProVen Professional – Study – The ProChild Study

The ProChild Study

Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool; a randomized controlled pilot study

Swansea Baby Trial

ProChild

Cambridge IBS Trial

Hertfordshire Study

Qatar Study

Cardiff Tracking Study

In Vitro Studies

Animal Studies

Aim

This randomised, double-blind, placebo controlled study aimed to show that the Lab4 probiotics with vitamin C had the capability of significantly reducing the symptoms of coughs and colds in young children, who are most susceptible age group.

Method

  • 57 children aged 3-6 years were divided into two groups.
  • The first group received daily for 6 months a chewable tablet containing the 12.5 billion Lab4 probiotics plus 50 mg Vitamin C (ProVen Fit for School), whilst the second group took a placebo.
  • The upper respiratory tract infections characterised by symptoms of sore throat, coughing, sneezing, blocked or runny nose, the absence from preschool and prescription of medications were recorded daily for 6 months.

The results

  • 49% significant reduction in the duration of coughs and colds total symptoms with the Lab4 probiotics and Vitamin C compared to placebo (Fig 1, *P<0.05).
  • 33% significant reduction in the incidence of coughs and colds symptoms in children taking the Lab4 probiotics and Vitamin C (Fig 2, *P<0.05).

Fig 1 Total Number of Days with Cough and Cold Symptoms

  • Placebo
  • Lab4+Vitamin C
  • Significant reduction in the use of cough and cold medicine with the Lab4 probiotics and Vitamin C (Fig 3, *P<0.05)

Fig 3 Total Number of Days of Medication usage

  • Placebos
  • Lab4+vitamin C
  • 24.1% of children in placebo group received oral antibiotics compared to only 14.3% children taking the Lab4 probiotics and Vitamin C

Fig 4 Number of Children with at least One Day of Oral Antibiotic use

  • Placebo
  • Lab4+vitamin C
  • 30% significant reduction in the incidence of absenteeism from school in children taking the Lab4 probiotics and Vitamin C (P=0.007). Number of days with absence due to coughs and colds alone were virtually halved in children taking the Lab4 probiotics and Vitamin C (Fig 5, 14.2 days in placebo vs 7.5 days in the Lab4 probiotics and Vitamin C group).

Fig 5 Total Number of Days Absent from Preschool Facilities

  • Placebo
  • Lab4+vitamin C
  • The number of visits to the G.P for any reason was reduced by 43% with the use of Lab4 probiotics and Vitamin C (Fig 6).

Fig 6 Total Number Of Physician Visits

  • Placebo
  • Lab4+Vitamin C

Conclusion

The Fit for School probiotics significantly reduced the incidence and duration of coughs and colds and absenteeism from school.

Reference

Garaiova I et al 2015.
Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study.
European Journal of Clinical Nutrition 69: 373-379.

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