ProVen Professional – Study – The Swansea Baby Trial

The Swansea Baby Study

Probiotics in the prevention of eczema: a randomized controlled trial

Swansea Baby Trial


Cambridge IBS Trial

Hertfordshire Study

Qatar Study

Cardiff Tracking Study

In Vitro Studies

Animal Studies


This large randomised, double blind, placebo controlled study aimed to confirm that Lab4b probiotics given during infancy can prevent allergy in children and hence potentially reduce the lifelong incidence of the condition.


  • The study was carried out at Swansea University Medical School
  • 454 mother/baby pairs took part in the trial
  • Half of the mothers took 10 billion of the Lab4b group of probiotics per day during the last month of pregnancy and then gave the same probiotic to their newborn babies every day for 6 months following birth
  • Half the mothers and babies took the placebo preparation
  • Skin prick tests were carried out on both the Lab4b probiotic and placebo infant groups to detect allergic reaction, the most common allergens including cow’s milk, egg, house dust mite and pollen

The results

  • The babies given Lab4b were 57% less likely to develop atopic eczema than those receiving the placebo
  • The babies given Lab4b were 44% less likely to develop allergic reaction to the common allergens including pollen, cow’s milk, egg and house dust mite

Atopic Eczema - Infants (%)

  • Placebo
  • Lab4b

Atopic Sensitization - SPT POSITIVE (%)

  • Placebo
  • Lab4b


The primary author, Prof. Steve Allen, concluded the following key message from the trial…


‘Lactobacilli and Bifidobacteria administered to pregnant women and infants aged 0-6 months prevented atopic sensitization and atopic eczema.’


Allen SJ et al 2014.
Probiotics in the prevention of eczema: a randomised controlled trial.
Archives of Disease in Childhood 99(11): 1014–1019

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