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ProVen Professional - Lab4 page

Lab4

The Lab4 and Lab4b consortia of bacteria, which the ProVen Probiotics products contain, were developed based upon a 30-year history of research and development in the probiotic industry – first with animals and subsequently with humans.

What are Lab4 and Lab4b?

Lab4 and Lab4b are lactic acid bacteria (LAB) that have been isolated from the gut flora of healthy humans and then screened for appropriate probiotic characteristics, ranging from resistance to stomach and bile acids, to robust capability for large-scale in-vitro cultivation and commercialisation.

The Lab4 consortium combines four strains of lactic acid bacteria isolated from human gut flora - two strains of Lactobacillus acidophilus, one Bifidobacterium animalis subsp. lactis and a Bifidobacterium bifidum.

The Lab4b consortium also combines four strains of lactic acid bacteria that have been specifically designated to reflect the gut of newborn babies and infants. This combination contains the same Bifidobacterium animalis subsp. lactis and Bifidobacterium bifidum as the Lab4 consortium, but contains Lactobacillus salivarius and Lactobacillus paracasei instead of the two Lactobacillus acidophilus strains.

lab4

Lactobacillus acidophilus – CUL60
Lactobacillus acidophilus – CUL21
Bifidobacterium bifidum - CUL20
Bifidobacterium animalis subsp. lactis - CUL34

lab4b

Lactobacillus salivarius - CUL61
Lactobacillus paracasei - CUL08
Bifidobacterium bifidum - CUL20
Bifidobacterium animalis subsp. lactis - CUL34

Since their inception, the Lab4 and Lab4b consortia have been the subject of more than 10 major human clinical trials as well as over 100 basic and mechanistic scientific investigations. Most of this work has been published in peer-reviewed journals.

Background to Lab4 and Lab4b

The isolation and selection of bacterial strains suitable for inclusion in human probiotic products involved a two-stage screening program of organisms based on a range of characteristics.

The program of testing was based on microbiological principles coupled with in vitro screening techniques and first-hand knowledge of the efficacy of probiotics within the animal husbandry sector.

Selection was based on a two-phase system to ‘weed out’ strains at various stages through the selection process to enable the most appropriate strains to be selected.

Two of the key requirements for the strains were durability and ‘competitivity’ - to ensure good growth and the ability to survive when faced with opportunistic pathogens.

Things you should know about Lab4 probiotics

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    Human strains

    Lab4 and Lab4b strains are benign microorganisms cultured from humans.

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    Colonise digestive tract

    Resistant to stomach acid and bile salts and capable of attachment to epithelial cells.

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    No gas

    Acidophilus and Bifidus are non-gas forming strains of bacteria.

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    Beneficial effects

    Lactic acid bacteria have frequently been shown to generate beneficial effects.

Probiotic Selection

The selected probiotic organisms were screened and selected using the following criteria:

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