Research & Manufacture

Research & Manufacture

The group of bacteria used in the ProVen Probiotics range is backed by a unique body of research supporting the benefits of these bacteria for different lifestages and health complaints.

From pregnancy, through infancy and childhood and into adulthood, the Lab4 friendly bacteria used in the ProVen Probiotics products have been used in research into allergy, common illnesses and specific digestive complaints, including bloating, irritable bowel syndrome (IBS) and Clostridium difficile (C. difficile) diarrhoea. They have also been shown to be safe to use and to support gut balance during and after antibiotic therapy.


Continuous research & development

The Lab4 friendly bacteria used in ProVen Probiotics is one of the most studied groups of friendly bacteria in the world and the most studied in the UK.

ProVen Probiotics are supported by a large body of ongoing research, with more than 40 published scientific papers, including nine major human studies, all demonstrating positive benefits in intestinal and immune heath.

Cultech Ltd (ProVen Probiotics’ parent company) is licensed by the MHRA to produce probiotics for clinical studies. Approval to give probiotics to almost 500 healthy newborn babies for the Swansea Baby Study is testament to the quality and safety of our products.

Unique bacteria for unique benefits

Probiotics are different from other supplements in that bacterial strain differences mean that benefits can be specific to an individual product. Ongoing research and a detailed understanding of the developments in the probiotic industry are both necessary to stay ahead of the game.

Research is at the heart of the Cultech and ProVen Probiotics operations and the company employs a large team of scientists and researchers. It has had studies published in more than 75 peer-reviewed publications and funded 16 PhDs, establishing an evidence base of health benefits to support its products.

Working with leading universities and hospitals, many in the UK, the research team works continuously to remain up-to-date with the latest industry research and developments.

Testament to this is the development of Lab4b for babies and the recent discovery of Lab4p, a brand new bacterial strain that has been shown to help reduce cholesterol.

cultech probiotic research

World-class manufacturing & production in the UK

Manufactured at the Cultech GMP (Good Manufacturing Process) approved manufacturing facility in the UK, ProVen Probiotics are produced using two proprietary manufacturing processes - Tri-Phase and StabilityMax.


Developed by the scientists at Cultech, Tri-Phase is a unique three-stage stabilising and conditioning technology, which increases stability of the probiotics at every stage of the process.


Phase 1

Stabilising and freeze-drying the probiotics

Phase 2

Pre-conditioning and tempering the product during manufacturing

Phase 3

Final treatment prior to packaging
Stability Max logo

Stability Max combines the TriPhase treated active ingredients with optimised 'gas-tight' packaging and 'overage' (extra) of bacteria.

The result is high potency probiotics, which are stable for up to 18 months at temperatures of up to 25°C. ProVen Probiotics guarantee that our products will always meet the label claim for the number of bacteria – the number on the label is the minimum count for each capsule, tablet or serving.


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